Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland

Status: Recruiting
Location: See location...
Intervention Type: Genetic, Diagnostic test, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to perform a detailed description of the feno- and genotype of people living with type 2 diabetes and severe obesity who are linked to care at Steno Diabetes Center Greenland. The main questions it aims to answer are: * Are monogenetic diabetes variants associated with the same risk of developing late diabetic complications as other types of diabetes? * Can genotyping and thereby personalized medicine be implemented in Greenland, and can personalized medicine lead to improved treatment? * What is the prevalence of sleep apnea among high-risk individuals in Greenland? * Is it possible to develop and implement a simple algorithm for the identification of sleep apnea in Greenland that can ensure treatment of severe sleep apnea? Participants will: * Answer WHO-5 and FOSQ-10 questionnaires regarding quality of life and functional outcomes of sleepiness * Perform VAGUS examinations for Cardiovasculare Autonomic Neuropathy * Clinical examination of height, weight, circumference of hip, waist and neck, Friedman tonsil and tongue score, nasal air flow, nasal septal deviation * Blood samples for full genome sequencing

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Type 2 diabetes and/or morbid obesity (BMI \>40)

• Over 18 years old

Locations
Other Locations
Greenland
Steno Diabetes Center Greenland, Queen Ingrids Hospital
RECRUITING
Nuuk
Contact Information
Primary
Mads Jensen, MD.
MMSN@peqqik.gl
+299 34 46 23
Backup
Marit Eika Jørgensen, MD. Ph.d
MAEJ@peqqik.gl
+299 34 43 24
Time Frame
Start Date: 2022-07-15
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 1000
Treatments
Experimental: Intervention arm
All participants will undergo examination for genom sequencing, diabetic complications and obstructive sleep apnea. Treatment for these conditions will not be randomized, but will be offered any participant who fulfills the excision treatment criteria
Sponsors
Collaborators: University of Copenhagen, Zealand University Hospital
Leads: Steno Diabetes Center Greenland

This content was sourced from clinicaltrials.gov